Four decades as a visual artist and professor (at Wayne State University) have made Margi Weir fluent in the intricacies of visual language. She writes in high-contrast pictograph, mixing contemporary and ancient symbols to create patterned and highly ordered works. Her carefully chosen symbols are repeated and confined to their respective registers, communing with each other in juxtaposition to create something more than a narrative: an exposition.

She has had solo exhibitions at Ivan Karp's OK Harris Gallery in New York, the Ruth Bachofner Gallery in Santa Monica, the Still/Zinsel Gallery in New Orleans, and Arnesen Fine Arts, Ltd in Vail. In 2009, the Las Cruces Museum of Art presented a three-decade retrospective of her work. Recent exhibitions have been at the 95th Toledo Area Artists Exhibition at the Toledo Museum of Art, Hunter/Gatherer at Truman State University, A Matter of Taste at the Michigan Women's Historical Center and Hall of Fame, Works on Paper NYC III at the Jeffrey Leder Gallery (all 2014) and (in 2013) Eye of the D: Seeing Detroit with New Eyes at the 555 Gallery and Studios and Miniatures and More 2013 at the Albuquerque Museum of Art and History.